caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss

low calorie diets are always difficult for obese subjects to follow and lead to metabolic and behavioral adaptation. therefore, we evaluated the effect of caffeine treatment with calorie shifting diet (csd) on weight loss. female subjects (n=98; bmi≥25) completed 4-weeks control diet, 6-weeks csd (3 repeated phases; each 2-weeks) and 4-weeks follow-up diet, with or without caffeine treatment (5mg/kg/day). the first 11 days of each phase included calorie restriction with four meals every day and 4 hours intervals. significant weight and fat loss were observed after 4-weeks of csd (5.7 ±1.24 kg and 4.84±1.53 kg) or csd+caffeine (7.57±2.33 kg and 5.24±2.07 kg) which was consistent for one month of the follow-up (csd: 5.24±1.83 kg and 4.3±1.62 kg, csd+caffeine: 12.11±2.31 kg and 9.85±1.6 kg, pthese findings indicated that combination of caffeine treatment with csd could be an effective alternative approach to weight and fat loss with small changes in rmr and improved tolerance of subjects to the new diet.